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Di  Zhang  lab 

at Peking University

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Publications:

(*Co-first author, # Corresponding author)

At PKU:

1.  Ren H, Tang Y, Zhang D#. The emerging role of protein L-lactylaation in metabolic regulation and cell signaling. Nat Metab. 2025.

  • doi: https://doi.org/10.1038/s42255-025-01259-0

 

2. Zhang D*, Gao J*, Zhu Z*, Mao Q, Xu Z, Singh PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, Sin YC, Chen Y, Olsen CA, Snyder NW, Dai L, Li L, Zhao Y. Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis. Nat Chem Biol2025 Jan;21(1):91-99. doi: 10.1038/s41589-024-01680-8. 

 

3. Ren H, Zhang D#Lactylation constrains OXPHOS under hypoxia, Cell Res2024 Feb;34(2):91-92. doi: 10.1038/s41422-023-00872-6.

 

4. Gao Y, Sheng X, Du J, Zhang D, Han C, Chen Y, Wang C, Zhao Y. ldentification of 113 new histone marks by &HiMA, a tailored database search strategy. Sci Adv. 2023 Apr 5;9(14):eadf1416. doi: 10.1126/sciadv.adf1416.

 

5. Moreno-Yruela, C*., Zhang, D*., Wei, W., Bæk, M., Liu, W., Gao, J., Danková, D., Nielsen, A. L., Bolding, J. E., Yang, L., Jameson, S. T., Wong, J., Olsen, C. A., & Zhao, Y. Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv. 2022 Jan 21;8(3):eabi6696. doi: 10.1126/sciadv.abi6696.

 

Before PKU:

6. Huang H*, Zhang D*, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y. The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Sci Adv. 2021 Feb 24;7(9):eabe2771. doi: 10.1126/sciadv.abe2771. 


7. Zhang D*, Tang Z*, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman H, Ding J, Dai L, Ren B, Robert RG, Becker L, Zhao Y. Metabolic regulation of gene expression by histone lactylation. Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1. 


8. Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y. Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.

9. Sabari BR*, Zhang D*, Allis CD, Zhao Y. Metabolic Regulation of Gene Expression through Differential Histone Acylation. Nat Rev Mol Cell Biol. 2017 Feb;18(2):90-101. doi: 10.1038/nrm.2016.140. 


10. Xie Z*, Zhang D*, Chung D*, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation. Mol Cell. 2016 Apr 21;62(2):194-206. doi: 10.1016/j.molcel.2016.03.036. 


11. Goudarzi A*, Zhang D*, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y‡, Khochbin 330327199802024412‡. Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol Cell. 201Apr 21;62(2):169-180. doi: 10.1016/j.molcel.2016.03.014. 


12. Zhang Y*, Zhang D*, Liang J, Yi X, Gui B, Yu W, Sun L, Yang X, Han X, Chen Z, Liu S, Si W, Yan R, Wang Y, Shang Y‡. Nucleation of DNA Repair Factors by FOXA1 Links DNA Demethylation to Transcriptional Pioneering. Nat Genet. 2016 Sep;48(9):1003-13. doi: 10.1038/ng.3635. 


13. Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, He L, Li W, Yi X, Sun L, Liang J, Cheng Z, Shi L, Yu W, Shang Y‡. SIRT7 Is a Histone Desuccinylase that Functionally Links to Chromatin Compaction and Genome Stability. Nat Commun. 2016 Jul 20:7:12235. doi: 10.1038/ncomms12235. 

 


 

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